Degradation of chondroitin sulfate by the gut microbiota of Chinese individuals.

  title={Degradation of chondroitin sulfate by the gut microbiota of Chinese individuals.},
  author={Qingsen Shang and Yeshi Yin and Liying Zhu and Guoyun Li and Guangli Yu and Xin Wang},
  journal={International journal of biological macromolecules},
Oral preparations of chondroitin sulfate (CS) have long been used as anti-osteoarthritis (anti-OA) drugs. However, little is known about the degradation of CS by human gut microbiota. In the present study, degradation profiles of CSA (the main constituent of CS drugs) by the human gut microbiota from six healthy subjects were investigated. Each individual's microbiota had differing degradation activities, but ΔUA-GalNAc4S was the end product in all cases. To elucidate the mechanisms underlying… CONTINUE READING
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