Degradation of carmustine in aqueous media.

  title={Degradation of carmustine in aqueous media.},
  author={P A Laskar and J. W. Ayres},
  journal={Journal of pharmaceutical sciences},
  volume={66 8},
The degradation rate of carmustine was investigated in buffered aqueous media at several pH values. The buffering agents studied were those with potential use in parenteral formulations of this drug: acetate, citrate, and phosphate. The apparent first-order degradation rate constants were calculated using a linear regression procedure. A pH range over which minimum degradation occurred was ascertained. General acid and specific base catalysis was demonstrated for the degradation of carmustine… CONTINUE READING