Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.

@article{Qiu1996DegradationOA,
  title={Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.},
  author={Weiliang Qiu and Wolfgang Borth and Zhiyun Ye and Christian Haass and David B Teplow and Dennis J Selkoe},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 14},
  pages={8443-51}
}
Progressive cerebral deposition of the amyloid beta-peptide (Abeta) is an early and constant feature of Alzheimer's disease. Abeta is derived by proteolysis from the beta-amyloid precursor protein. beta-Amyloid precursor protein processing and the generation of Abeta have been extensively characterized, but little is known about the mechanisms of degradation of this potentially neurotoxic peptide. We identified and purified a proteolytic activity in culture medium that can degrade secreted… CONTINUE READING