Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM [ subscript 3 ] Ubiquitin Ligase in Rat Hippocampal

@inproceedings{Hung2010DegradationOP,
  title={Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM [ subscript 3 ] Ubiquitin Ligase in Rat Hippocampal},
  author={Albert Y. C. Hung and Clifford C. Sung and Ilana L. Brito and Morgan Sheng},
  year={2010}
}
Changes in neuronal activity modify the structure of dendritic spines and alter the function and protein composition of synapses. Regulated degradation of postsynaptic density (PSD) proteins by the ubiquitin-proteasome system is believed to play an important role in activity-dependent synaptic remodeling. Stimulating neuronal activity in vitro and in vivo induces the ubiquitination and degradation of GKAP/SAPAP and Shank, major scaffold proteins of the PSD. However, the specific ubiquitin… CONTINUE READING

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