Degradation of NF-κB in T Cells by Gangliosides Expressed on Renal Cell Carcinomas

@inproceedings{Thornton2004DegradationON,
  title={Degradation of NF-κB in T Cells by Gangliosides Expressed on Renal Cell Carcinomas},
  author={Mark V. Thornton and Daisuke Kudo and Patricia A. Rayman and Claudine Horton and Lu{\'i}s Molt{\'o} and Martha K. Cathcart and Christopher Kiat Soon. Ng and Ewa Paszkiewicz-Kozik and Ronald M. Bukowski and Ithaar H Derweesh and Charles S. Tannenbaum and James Harold Finke},
  year={2004}
}
T cells from cancer patients are often functionally impaired, which imposes a barrier to effective immunotherapy. Most pronounced are the alterations characterizing tumor-infiltrating T cells, which in renal cell carcinomas includes defective NF-κB activation and a heightened sensitivity to apoptosis. Coculture experiments revealed that renal tumor cell lines induced a time-dependent decrease in RelA(p65) and p50 protein levels within both Jurkat T cells and peripheral blood T lymphocytes that… CONTINUE READING

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