Degradation of C3 by Streptococcus pneumoniae.

  title={Degradation of C3 by Streptococcus pneumoniae.},
  author={C S Angel and M Ruzek and Margaret Kendrick Hostetter},
  journal={The Journal of infectious diseases},
  volume={170 3},
After growth to exponential phase in Todd-Hewitt broth, clinical and laboratory isolates of Streptococcus pneumoniae serotypes 3, 4, and 14 readily degraded first the beta and then the alpha chains of purified human C3 in the absence of serum or other complement proteins, as assessed by SDS-PAGE. With exponentially growing pneumococci, degradation of native… CONTINUE READING