Degradation of Amyloid β Protein by Purified Myelin Basic Protein*

@article{Liao2009DegradationOA,
  title={Degradation of Amyloid $\beta$ Protein by Purified Myelin Basic Protein*},
  author={Mei-Chen Liao and Mahiuddin Ahmed and Steven O. Smith and W. V. Van Nostrand},
  journal={The Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={28917 - 28925}
}
The progressive accumulation of β-amyloid (Aβ) in senile plaques and in the cerebral vasculature is the hallmark of Alzheimer disease and related disorders. Impaired clearance of Aβ from the brain likely contributes to the prevalent sporadic form of Alzheimer disease. Several major pathways for Aβ clearance include receptor-mediated cellular uptake, blood-brain barrier transport, and direct proteolytic degradation. Myelin basic protein (MBP) is the major structural protein component of myelin… Expand
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Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation*
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