Degradation mechanism and stability of 5-aminolevulinic acid.

  title={Degradation mechanism and stability of 5-aminolevulinic acid.},
  author={Amie Jo Bunke and Oliver Zerbe and Hiltru Schmid and Gerd Burmeister and Hans Peter Merkle and Bruno A Gander},
  journal={Journal of pharmaceutical sciences},
  volume={89 10},
The physiological substance and precursor of the heme synthesis 5-aminolevulinic acid (ALA) is a promising prodrug for photodiagnosis and photodynamic therapy of epithelial tumors, particularly in urological and gynecological tissues. For the clinical use of this substance, a chemically stable and sterile drug formulation is required. In the present study, degradation mechanism of ALA in aqueous solution and possibilities to improve its stability were examined. A capillary electrophoretic… CONTINUE READING


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