Degradation Kinetics of Oxycarbonyloxymethyl Prodrugs of Phosphonates in Solution

  title={Degradation Kinetics of Oxycarbonyloxymethyl Prodrugs of Phosphonates in Solution},
  author={L Yuan and Terrence C. Dahl and Reza Oliyai},
  journal={Pharmaceutical Research},
Phosphonate analogs of nucleotides have recently received considerable attention as potential antiviral agents. The ionic character of these agents limits their permeability across the human intestinal mucosa, resulting in low bioavailability after oral administration (1,2). We have previously demonstrated the utility of the bis-isopropyloxycarbonylmethyl (bis-POC) moiety in improving the oral bioavailability of phosphonate nucleotides (3–5). The bis-POC promoiety utilizes the… CONTINUE READING


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