Deglycosylation is a key step in biotransformation and lifespan effects of quercetin-3-O-glucoside in Caenorhabditis elegans.

@article{Dueas2013DeglycosylationIA,
  title={Deglycosylation is a key step in biotransformation and lifespan effects of quercetin-3-O-glucoside in Caenorhabditis elegans.},
  author={Montserrat Due{\~n}as and Felipe Surco-Laos and Susana Gonz{\'a}lez-Manzano and Ana Mar{\'i}a Gonz{\'a}lez-Param{\'a}s and Eva G{\'o}mez-Orte and Juan Carlos Cabello and Celestino Santos-Buelga},
  journal={Pharmacological research},
  year={2013},
  volume={76},
  pages={41-8}
}
Due to their purported healthful activities, quercetin and other flavonoids are being increasingly proposed as nutraceuticals. Quercetin occurs in food as glycosides; however, most assays on its activity have been performed with the aglycone, despite glycosylation deeply affects compound bioavailability. In this work, the uptake and lifespan effects of quercetin-3-O-glucoside (Q3Glc) and quercetin have been assessed in Caenorhabditis elegans. Q3Glc was taken up by this nematode in a… CONTINUE READING

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