Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis.

@article{FordHutchinson2005DegenerativeKJ,
  title={Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis.},
  author={Alice Fiona Ford-Hutchinson and Zenobia Ali and Ruth Anne Seerattan and David Michael Lane Cooper and Benedikt Hallgr{\'i}msson and Paul T. Salo and Frank Robert Jirik},
  journal={Osteoarthritis and cartilage},
  year={2005},
  volume={13 5},
  pages={418-25}
}
OBJECTIVE Murine brachymorphism (bm) results from an autosomal recessive mutation of the Papss2 gene that encodes 3'-phosphoadenosine 5'-phosphosulfate synthetase 2, one of the principal enzymes required for the sulfation of extracellular matrix molecules in cartilage and other tissues. A spondyloepimetaphyseal dysplasia has been identified in Pakistani… CONTINUE READING