Degenerative joint disease in the guinea pig. Use of magnetic resonance imaging to monitor progression of bone pathology.

@article{Watson1996DegenerativeJD,
  title={Degenerative joint disease in the guinea pig. Use of magnetic resonance imaging to monitor progression of bone pathology.},
  author={P J Watson and Laurance D. Hall and A. Malcolm and Jenny A. Tyler},
  journal={Arthritis and rheumatism},
  year={1996},
  volume={39 8},
  pages={
          1327-37
        }
}
OBJECTIVE The suitability of magnetic resonance imaging (MRI) for serial monitoring of bone pathology in the guinea pig stifle joint, an in vivo model of osteoarthritis, was investigated. METHODS MR images were compared with histologic features and radiographs of 1-mm-thick sections to determine the MR correlates of the bone changes. Ten guinea pigs were then imaged on 7 occasions over the first year of life, enabling serial measurements of subchondral bone thickness, subchondral pseudocysts… CONTINUE READING

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