Degenerative and axon outgrowth-altering effects of phencyclidine in human fetal cerebral cortical cells

@article{Mattson1992DegenerativeAA,
  title={Degenerative and axon outgrowth-altering effects of phencyclidine in human fetal cerebral cortical cells},
  author={Mark P. Mattson and Błażej Rychlik and B Z Cheng},
  journal={Neuropharmacology},
  year={1992},
  volume={31},
  pages={279-291}
}
  • Mark P. Mattson, Błażej Rychlik, B Z Cheng
  • Published 1992
  • Psychology, Medicine
  • Neuropharmacology
  • Babies born to mothers abusing the psychotomimetic drug phencyclidine (PCP), often show profound deficits in CNS function. It is now reported that PCP can cause progressive degeneration and death in human fetal cerebral cortical neurons in culture and sublethal levels of PCP can inhibit axon outgrowth. In cerebral cortical cell cultures established from 14 week fetuses, exposure to 500 microM PCP resulted in a progressive degeneration of neurons over a 2-8 day period, characterized by early… CONTINUE READING