Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity.

  title={Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity.},
  author={Christel Dentel and Lavinia Palamiuc and Alexandre Henriques and B{\'e}atrice Lannes and Odile Spreux-Varoquaux and L. M. Gutknecht and Fr{\'e}d{\'e}rique Ren{\'e} and Andoni Echaniz-Laguna and Jos{\'e}-Luis Gonzalez de Aguilar and Klaus-Peter Lesch and Vincent Meininger and J. -P. Loeffler and Luc Dupuis},
  journal={Brain : a journal of neurology},
  volume={136 Pt 2},
Spasticity is a common and disabling symptom observed in patients with central nervous system diseases, including amyotrophic lateral sclerosis, a disease affecting both upper and lower motor neurons. In amyotrophic lateral sclerosis, spasticity is traditionally thought to be the result of degeneration of the upper motor neurons in the cerebral cortex, although degeneration of other neuronal types, in particular serotonergic neurons, might also represent a cause of spasticity. We performed a… CONTINUE READING
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