Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study

@article{Oestreicher1994DegenerationON,
  title={Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study},
  author={Elmar Oestreicher and Gregory J. Sengstock and Peter Riederer and Charles W. Olanow and Gary W. Arendash},
  journal={Brain Research},
  year={1994},
  volume={660},
  pages={8-18}
}
Parkinson's-diseased (PD) brains have increased levels of iron in the zona compacta of the substantia nigra (SNc). To determine whether these elevated nigral iron levels may be caused secondarily by degeneration of nigrostriatal dopaminergic (NS-DA) neurons, the NS-DA pathway was unilaterally lesioned in rats through 6-hydroxydopamine (6-OHDA) infusion and nigral iron levels evaluated three weeks later. A significant increase was observed in both iron concentration (+35%) and iron content (+33… CONTINUE READING

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