Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor

@article{Yoshikawa1992DegenerationIV,
  title={Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor},
  author={Kazuaki Yoshikawa and Takako Aizawa and Yokichi Hayashi},
  journal={Nature},
  year={1992},
  volume={359},
  pages={64-67}
}
A PATHOLOGICAL hallmark of Alzheimer's disease is the deposition of amyloid fibrils in the brain. The principal component of amyloid fibrils is β/A4 amyloid protein1,2, which can be generated by the aberrant processing of a large membrane-bound glycoprotein, the β/A4 amyloid protein precursor (APP)3. To test whether overexpression of APP generates abnormally processed derivatives that affect the viability of neurons, we stably transfected full-length human APP complementary DNA into murine… CONTINUE READING