Degenerate recognition of alloantigenic peptides on a positive-selecting class I molecule.

@article{Tallquist1998DegenerateRO,
  title={Degenerate recognition of alloantigenic peptides on a positive-selecting class I molecule.},
  author={Michelle D. Tallquist and Arthur J. Weaver and Larry R. Pease},
  journal={Journal of immunology},
  year={1998},
  volume={160 2},
  pages={802-9}
}
The well-defined 2C T cell was used to investigate alloreactive degeneracy. A panel of class I molecules that are known ligands for the 2C TCR were sensitized with three known peptide ligands, p2Ca (LSPFPFDL), dEV-8 (EQYKFYSV), and SIYR-8 (SIYRYYGL). The peptide p2Ca was originally identified as the allopeptide seen in the Ld class I molecule by 2C T cells, 2C recognizes the dEV-8 peptide as the ligand in the Kbm3 class I molecule, and SIYR-8 was recently identified as a peptide ligand for 2C… CONTINUE READING

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