Deformation of the lamina cribrosa by elevated intraocular pressure.

  title={Deformation of the lamina cribrosa by elevated intraocular pressure.},
  author={David B Yan and Francisco Coloma and Ankana Metheetrairut and Graham E. Trope and J. Godfrey Heathcote and C. Ross Ethier},
  journal={The British journal of ophthalmology},
  volume={78 8},
The purpose of this study was to determine the mechanical response of the lamina cribrosa (LC) to elevated intraocular pressure (IOP) so as to identify possible mechanisms of optic nerve damage in early glaucoma. Ten pairs of normal human eyes were fixed after 24 hours' exposure to 50 mm Hg pressure (experimental eyes) or 5 mm Hg pressure (contralateral control eyes). Photomicrographs of the central region of the optic nerve head (ONH) were taken to examine the LC morphologically and to measure… CONTINUE READING


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