Defluorinated Sparfloxacin as a New Photoproduct Identified by Liquid Chromatography Coupled with UV Detection and Tandem Mass Spectrometry

@article{Engler1998DefluorinatedSA,
  title={Defluorinated Sparfloxacin as a New Photoproduct Identified by Liquid Chromatography Coupled with UV Detection and Tandem Mass Spectrometry},
  author={M. Engler and G. Ruesing and F. Soergel and U. Holzgrabe},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1998},
  volume={42},
  pages={1151 - 1159}
}
  • M. Engler, G. Ruesing, +1 author U. Holzgrabe
  • Published 1998
  • Chemistry, Medicine
  • Antimicrobial Agents and Chemotherapy
  • ABSTRACT Photodegradation of sparfloxacin was observed by means of high-pressure liquid chromatography with UV detection and liquid chromatography coupled with UV detection and tandem mass spectrometry (LC-MS/MS). Three products were detected. Comparison with an independently synthesized derivative of sparfloxacin revealed the structure of one product which is believed to be 8-desfluorosparfloxacin. The second product is likely to be formed by the splitting off of a fluorine and a cyclopropyl… CONTINUE READING
    30 Citations
    Characterization of clinafloxacin photodegradation products by LC-MS/MS and NMR.
    • 27
    Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: a review
    • 54
    Photophysics and photochemistry of fluoroquinolones.
    • 196
    Structural elucidation of gemifloxacin mesylate degradation product.
    • 1

    References

    SHOWING 1-10 OF 15 REFERENCES
    Photodegradation products of levofloxacin in aqueous solution.
    • 37
    Structure elucidation of a photodegradation product of ciprofloxacin.
    • 38
    PHOTOSENSITIZATION BY DRUGS: NALIDIXIC AND OXOLINIC ACIDS
    • 43
    The loss of antibiotic activity of ciprofloxacin by photodegradation.
    • 54