Definitive chromosomal location of the H-2 complex by in situ hybridization to pachytene chromosomes

Abstract

Chromosome 17 of the mouse carries the H-2 complex and the T/t complex. An understanding of the organization of this region and an accurate genetic map of chromosome 17 would be of great value for both immunologists and developmental biologists. Until now the only maps available have been derived solely from recombinational studies using several translocations, an inherently inaccurate method. We have found the definitive location of the H-2 complex by the use of in situ hybridization. Our results show that both the T/t complex and the H-2 complex map to positions far more distal than the generally accepted map positions. This proves that recombination in Robertsonian chromosomes underestimates physical map distances on chromosome 17.

DOI: 10.1007/BF00430593

2 Figures and Tables

Statistics

0200400600'88'91'94'97'00'03'06'09'12'15
Citations per Year

383 Citations

Semantic Scholar estimates that this publication has 383 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Lader1985DefinitiveCL, title={Definitive chromosomal location of the H-2 complex by in situ hybridization to pachytene chromosomes}, author={Eric Lader and B. Ted Clark and Suresh C. Jhanwar and R. S. K. Chaganti and Dorothea Bennett}, journal={Immunogenetics}, year={1985}, volume={22}, pages={49-54} }