Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus.

@article{Lin2001DefinitiveAO,
  title={Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus.},
  author={T. I. Lin and Cornelia Schroeder},
  journal={Journal of virology},
  year={2001},
  volume={75 8},
  pages={3647-56}
}
The viral ion channel protein M2 supports the transit of influenza virus and its glycoproteins through acidic compartments of the cell. M2 conducts endosomal protons into the virion to initiate uncoating and, by equilibrating the pH at trans-Golgi membranes, preserves the native conformation of acid-sensitive viral hemagglutinin. The exceptionally low conductance of the M2 channel thwarted resolution of single channels by electrophysiological techniques. Assays of liposome-reconstituted M2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Functional reconstitution of influenza A M2(22-62).

Biochimica et biophysica acta • 2011
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…