Definition of the single integration site of the pathogenicity locus in Clostridium difficile.

@article{Braun1996DefinitionOT,
  title={Definition of the single integration site of the pathogenicity locus in Clostridium difficile.},
  author={Volkmar Braun and Thomas Hundsberger and Petra Leukel and Markus Sauerborn and Christoph von Eichel-Streiber},
  journal={Gene},
  year={1996},
  volume={181 1-2},
  pages={29-38}
}
We determined the nucleotide sequence 3.8 kb upstream and 5.2 kb downstream of the toxin genes A and B of Clostridium difficile. Nine ORFs were discovered. Based on PCR-directed approaches, two were attributed to the pathogenicity locus (PaLoc). The other seven were found in every C. difficile isolate obtained from the human gastrointestinal tract, respectless of their toxinogenicity. The ORFs cdu1 and cdu2/2' upstream of the PaLoc displayed similarity to repressors of Gram-positive bacteria… CONTINUE READING
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