Definition of the p53 binding-site on the tms1 protein.

@article{Wagner1995DefinitionOT,
  title={Definition of the p53 binding-site on the tms1 protein.},
  author={Peter Wagner and Anne V. Fuchs and Wolfgang Nastainczyk},
  journal={International journal of oncology},
  year={1995},
  volume={7 1},
  pages={171-5}
}
Recently we described the cloning of the yeast tms1 gene by complementation of a lethal growth arrest caused by expression of a tumour mutant cDNA of p53 in fission yeast. The tms1 gene product was found to form stable complexes with p53 in yeast and in vitro using purified recombinant proteins the interaction was mapped to the C-terminal region of p53. Using a combination of a genetic and a synthetic approach we were able to establish the p53 binding site on the tms1 protein to the sequence… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-2 of 2 extracted citations

A Molecular and Cellular View of Protein Kinase CK2

Developments in Molecular and Cellular Biochemistry • 1999
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…