Definition of the initial immunologic modifications upon in vitro gliadin challenge in the small intestine of celiac patients.


BACKGROUND & AIMS Mucosal cell-mediated immune response is considered the central event in the pathogenesis of celiac disease. In cultured intestinal explants from celiacs in remission, we have characterized the early stages of gliadin-induced immune activation. METHODS Intestinal biopsy specimens (15 treated celiacs and 13 controls) were cultured with… (More)


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