Definition of the Extracellular Proteome of Pathogenic-Phase Histoplasma capsulatum

@inproceedings{Holbrook2011DefinitionOT,
  title={Definition of the Extracellular Proteome of Pathogenic-Phase Histoplasma capsulatum},
  author={Eric D. Holbrook and Jessica A. Edwards and Brian H. Youseff and Chad A Rappleye},
  booktitle={Journal of proteome research},
  year={2011}
}
The dimorphic fungal pathogen Histoplasma capsulatum causes respiratory and systemic disease. Within the mammalian host, pathogenic Histoplasma yeast infect, replicate within, and ultimately kill host phagocytes. Surprisingly, few factors have been identified that contribute to Histoplasma virulence. To address this deficiency, we have defined the constituents of the extracellular proteome using LC-MS/MS analysis of the proteins in pathogenic-phase culture filtrates of Histoplasma. In addition… CONTINUE READING