Definition of regions in human c-myc that are involved in transformation and nuclear localization.

@article{Stone1987DefinitionOR,
  title={Definition of regions in human c-myc that are involved in transformation and nuclear localization.},
  author={Joanne Stone and Titia de Lange and G. C. Ramsay and Edward B. Jakobovits and J. Michael Bishop and H. E. Varmus and Wen-Hwa Lee},
  journal={Molecular and cellular biology},
  year={1987},
  volume={7 5},
  pages={1697-709}
}
To study the relationship between the primary structure of the c-myc protein and some of its functional properties, we made in-frame insertion and deletion mutants of the normal human c-myc coding domain that was expressed from a retroviral promoter-enhancer. We assessed the effects of these mutations on the ability of c-myc protein to cotransform normal rat embryo cells with a mutant ras gene, induce foci in a Rat-1-derived cell line (Rat-1a), and localize in nuclei. Using the cotransformation… CONTINUE READING

From This Paper

Topics from this paper.
93 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 93 extracted citations

Similar Papers

Loading similar papers…