Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis.

@article{Tacken1999DefinitionOR,
  title={Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis.},
  author={Ingrid Tacken and Heike Dahmen and Olivier Boisteau and St{\'e}phane Minvielle and Yannick Jacques and Joachim Gr{\"o}tzinger and Andrea K{\"u}ster and Ursula Horsten and Chrystel Blanc and F{\'e}lix A. Montero-Julian and Peter Claus Heinrich and G M{\"u}ller-newen},
  journal={European journal of biochemistry},
  year={1999},
  volume={265 2},
  pages={645-55}
}
Interleukin-11 (IL-11) belongs to the interleukin-6 (IL-6)-type subfamily of long-chain helical cytokines including IL-6, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M, and cardiotrophin-1, which all share the glycoprotein gp130 as a signal transducing receptor component. IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) alpha-subunit (IL-11Ralpha). The structural epitopes of IL-11 required for the recruitment of the individual receptor… CONTINUE READING

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