Definition of membrane topology and identification of residues important for transport in subunit a of the vacuolar ATPase.

Abstract

Subunit a of the vacuolar H(+)-ATPases plays an important role in proton transport. This membrane-integral 100-kDa subunit is thought to form or contribute to proton-conducting hemichannels that allow protons to gain access to and leave buried carboxyl groups on the proteolipid subunits (c, c', and c″) during proton translocation. We previously demonstrated… (More)
DOI: 10.1074/jbc.M111.273409

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