Definition of a spliceosome interaction domain in yeast Prp2 ATPase.

  title={Definition of a spliceosome interaction domain in yeast Prp2 ATPase.},
  author={Gretchen Edwalds-Gilbert and D Kim and Edward J Silverman and Ren-Jang Lin},
  volume={10 2},
The Saccharomyces cerevisiae splicing factor Prp2 is an RNA-dependent ATPase required before the first transesterification reaction in pre-mRNA splicing. Prp2 binds to the spliceosome in the absence of ATP and is released following ATP hydrolysis. It contains three domains: a unique N-terminal domain, a helicase domain that is highly conserved in the DExD/H protein family, and a C-terminal domain that is conserved in spliceosomal DEAH proteins Prp2, Prp16, Prp22, and Prp43. We examined the role… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…