Definition of a region of loss of heterozygosity at chromosome 11q23.3-25 in head and neck squamous cell carcinoma using laser capture microdissection technique.

@article{Tan2004DefinitionOA,
  title={Definition of a region of loss of heterozygosity at chromosome 11q23.3-25 in head and neck squamous cell carcinoma using laser capture microdissection technique.},
  author={Dongfeng Tan and Sam Wiseman and Youtai Zhou and Qiang Li and Pamela P. Ward and Harry K. Slocum and Sadir J. Alrawi and Thom R. Loree and W. Hicks and Nestor R. Rigual and Garth R. Anderson and Daniel L. Stoler},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  year={2004},
  volume={13 1},
  pages={33-40}
}
To date, loss of heterozygosity (LOH) studies on HNSCC have had limited success in identifying a confined region of loss on chromosome 11q partially due to the heterogeneous nature of tumor tissue examined. Additionally, little is known about the role of the 11q allelic deletion in HNSCC tumorigenesis and current reports are conflicting. The aim of this study was to better define LOH at distal 11q by using combination of a pure cell population procured by laser capture microdissection (LCM) and… CONTINUE READING