Definition of a novel complementation group in MHC class II deficiency

  title={Definition of a novel complementation group in MHC class II deficiency},
  author={Ad Peijnenburg and Barbara C. Godthelp and Anette van Boxel-Dezaire and Peter J. van den Elsen},
In this study we analyzed fibroblasts derived from an MHC class II deficiency patient (type III bare lymphocyte syndrome). Northern blot analysis showed that upon induction with IFN-γ these fibroblasts did not express HLA class II genes and displayed a strongly reduced level of HLA class I gene expression when compared with fibroblasts of a healthy individual. However, when analyzed by RT-polymerase chain reaction (PCR), residual expression could be detected for HLA-DRA, DPB, and DQA, but not… CONTINUE READING
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