Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer

@inproceedings{Schildhaus2012DefinitionOA,
  title={Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer},
  author={Hans-Ulrich Schildhaus and Lukas Heukamp and Sabine Merkelbach-Bruse and Katharina Riesner and Katja Schmitz and Elke Binot and Ellen Paggen and Kerstin Albus and W. Roy Schulte and Y D Ko and Andreas Schlesinger and Sascha Ans{\'e}n and Walburga Engel-Riedel and Michael Brockmann and Monika Serke and Ulrich Gerigk and Sebastian Huss and Friederike G{\"o}ke and Sven Perner and Khosro Hekmat and Konrad F. Frank and Marcel Reiser and Roland Schnell and M. K. Bos and Christian Mattonet and Martin L Sos and Erich Stoelben and J{\"u}rgen Wolf and Thomas Zander and Reinhard H Buettner},
  booktitle={Modern Pathology},
  year={2012}
}
We recently reported fibroblast growth factor receptor-type 1 (FGFR1) amplification to be associated with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. This makes FGFR1 a novel target for directed therapy in these tumors. To reproducibly identify patients for clinical studies, we developed a standardized reading and evaluation strategy for FGFR1 fluorescence in-situ hybridization (FISH) and propose evaluation criteria, describe different patterns of low- and high… CONTINUE READING
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A phase I dose escalation study of NVP-BGJ398, a selective pan FGFR inhibitor in genetically preselected advanced solid tumors

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