Definition of a bacterial virulence factor: sialylation of the group B streptococcal capsule.

@article{Wessels1989DefinitionOA,
  title={Definition of a bacterial virulence factor: sialylation of the group B streptococcal capsule.},
  author={Michael R. Wessels and Craig E. Rubens and Vicente Javier Bened{\'i} and Dennis L Kasper},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 22},
  pages={8983-7}
}
Sialylation of bacterial capsules has been proposed as an important virulence factor for several species of encapsulated pathogens, including group B Streptococcus. We have constructed a transposon mutant strain of type III group B Streptococcus that expresses a capsular polysaccharide differing from the wild type only in that the mutant strain's capsule lacks sialic acid. The mutant polysaccharide is antigenically identical to the capsular polysaccharide of type 14 Streptococcus pneumoniae, as… CONTINUE READING

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