Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes.

  title={Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes.},
  author={Gunter von Minckwitz and Michael Untch and Jens-Uwe Blohmer and Serban D. Costa and Holger Eidtmann and Peter Andreas Fasching and Bernd Gerber and Wolfgang Eiermann and J{\"o}rn Hilfrich and Jens Huober and Christian Jackisch and Manfred Kaufmann and Gottfried E. Konecny and Carsten Denkert and Valentina Nekljudova and Keyur M Mehta and Sibylle Loibl},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={30 15},
  • G. von MinckwitzM. Untch S. Loibl
  • Published 20 May 2012
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE The exact definition of pathologic complete response (pCR) and its prognostic impact on survival in intrinsic breast cancer subtypes is uncertain. [] Key MethodRESULTS Disease-free survival (DFS) was significantly superior in patients with no invasive and no in situ residuals in breast or nodes (n = 955) compared with patients with residual ductal carcinoma in situ only (n = 309), no invasive residuals in breast but involved nodes (n = 186), only focal-invasive disease in the breast (n = 478), and…

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