Definition and epidemiology of treatment-resistant depression.

  title={Definition and epidemiology of treatment-resistant depression.},
  author={Maurizio Fava and Katharine G Davidson},
  journal={The Psychiatric clinics of North America},
  volume={19 2},
Our results suggest that between 29% and 46% of depressed patients fail to respond fully with antidepressant treatment of adequate dose and duration. In particular, although partial response appears to occur in 12% to 15% of the depressed patients studied, nonresponse is observed in 19% to 34% of this population. The prevalence of treatment-resistant depression derived from studies using ITT analysis is likely to be an overestimate of the actual occurrence of the phenomenon, as these rates also… CONTINUE READING
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