Definition and clinical relevance of antibodies to nuclear ribonucleoprotein and other nuclear antigens in patients with cryptogenic fibrosing alveolitis.

@article{Chapman1984DefinitionAC,
  title={Definition and clinical relevance of antibodies to nuclear ribonucleoprotein and other nuclear antigens in patients with cryptogenic fibrosing alveolitis.},
  author={Jennifer Chapman and Peter J. Charles and Patrick J W Venables and Phillip J. Thompson and Patricia L. Haslam and Ravinder N. Maini and M E Turner Warwick},
  journal={The American review of respiratory disease},
  year={1984},
  volume={130 3},
  pages={439-43}
}
Antinuclear antibodies (ANA) were studied in 122 patients with cryptogenic fibrosing alveolitis (CFA) and compared with age- and sex-matched control subjects. Fluorescent ANA were detected in 32% of the patients and showed a correlation with the presence of a systemic connective tissue disease; ANA were present in 6% of the control subjects, 21% of the patients with CFA alone, and 46% of those with CFA and an associated connective tissue disease. Antibodies to the defined nuclear antigens… CONTINUE READING

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