Definition and classification of the histamine-release response to drugs in anaesthesia and surgery: Studies in the conscious human subject

@article{Lorenz1982DefinitionAC,
  title={Definition and classification of the histamine-release response to drugs in anaesthesia and surgery: Studies in the conscious human subject},
  author={Professor Dr. Wilfried Lorenz and Alfred W Doenicke and Britta Sch{\"o}ning and Ch. Ohmann and Bill Grote and E. A. M. Neugebauer},
  journal={Klinische Wochenschrift},
  year={1982},
  volume={60},
  pages={896-913}
}
In 2 clinical studies in 40 conscious human volunteers and 164 orthopedic patients histamine-release responses were diagnosed, defined and classified. Polygeline (Haemaccel) in its now outdated formulation [40] was chosen as a clinical histamine releaser. The main interest was not concentrated on the extreme, the “classical” anaphylactic response, but on theaverage histamine-release response found in clinical experiments with so many drugs in the last 10 years. In human volunteers 600 ng/kg… CONTINUE READING

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