Defining the status of RNA polymerase at promoters.

  title={Defining the status of RNA polymerase at promoters.},
  author={Leighton J. Core and Joshua J Waterfall and Daniel A. Gilchrist and David C. Fargo and Hojoong Kwak and Karen Adelman and John T Lis},
  journal={Cell reports},
  volume={2 4},
Recent genome-wide studies in metazoans have shown that RNA polymerase II (Pol II) accumulates to high densities on many promoters at a rate-limited step in transcription. However, the status of this Pol II remains an area of debate. Here, we compare quantitative outputs of a global run-on sequencing assay and chromatin immunoprecipitation sequencing assays and demonstrate that the majority of the Pol II on Drosophila promoters is transcriptionally engaged; very little exists in a preinitiation… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 10 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
83 Citations
57 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 83 extracted citations


Publications referenced by this paper.
Showing 1-10 of 57 references

Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila

  • S. Nechaev, D. C. Fargo, G. dos Santos, L. Liu, Y. Gao, K. Adelman
  • 2010
Highly Influential
20 Excerpts

conductor package for differential expression analysis of digital gene expression data

  • A. E. Rougvie, J. T. Lis
  • engaged. Cell
  • 1988
Highly Influential
11 Excerpts

Similar Papers

Loading similar papers…