Defining the status of RNA polymerase at promoters.

@article{Core2012DefiningTS,
  title={Defining the status of RNA polymerase at promoters.},
  author={Leighton J. Core and Joshua J Waterfall and Daniel A. Gilchrist and David C. Fargo and Hojoong Kwak and Karen Adelman and John T Lis},
  journal={Cell reports},
  year={2012},
  volume={2 4},
  pages={1025-35}
}
Recent genome-wide studies in metazoans have shown that RNA polymerase II (Pol II) accumulates to high densities on many promoters at a rate-limited step in transcription. However, the status of this Pol II remains an area of debate. Here, we compare quantitative outputs of a global run-on sequencing assay and chromatin immunoprecipitation sequencing assays and demonstrate that the majority of the Pol II on Drosophila promoters is transcriptionally engaged; very little exists in a preinitiation… CONTINUE READING
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