Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism.

@article{Goldring2008DefiningTR,
  title={Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism.},
  author={Mary B Goldring and M Jes{\'u}s {\'A}lvarez Otero and Kaneyuki Tsuchimochi and Kosei Ijiri and Yingni Li},
  journal={Annals of the rheumatic diseases},
  year={2008},
  volume={67 Suppl 3},
  pages={
          iii75-82
        }
}
In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in response to alterations in the environment owing to mechanical injury and inflammation. These processes not only stimulate the production of enzymes that degrade the cartilage matrix but also inhibit repair. With the use of in vitro and in vivo models, new genes, not known previously to act in cartilage, have been identified and their roles in chondrocyte differentiation during development and in dysregulated… CONTINUE READING
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