Defining the role of the Bcl-2 family of proteins in the nervous system.

@article{Lindsten2005DefiningTR,
  title={Defining the role of the Bcl-2 family of proteins in the nervous system.},
  author={Tullia Lindsten and Wei-Xing Zong and Craig B Thompson},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year={2005},
  volume={11 1},
  pages={
          10-5
        }
}
The Bcl-2 family of apoptotic-regulating proteins plays important roles during both neural development and maintenance of tissue homeostasis. The major antiapoptotic family members, Bcl-x(L) and Bcl-2, and the major proapoptotic proteins, Bax and Bak, show distinct temporal and spatial patterns of expression in the developing brain. Targeted deletions of Bcl-x(L) and Bcl-2 as well as Bax and Bak have proven to be important tools in delineating the process of cell death in the nervous system… CONTINUE READING
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