Defining the role of mesenchymal stromal cells on the regulation of matrix metalloproteinases in skeletal muscle cells.

@article{Sassoli2014DefiningTR,
  title={Defining the role of mesenchymal stromal cells on the regulation of matrix metalloproteinases in skeletal muscle cells.},
  author={Chiara Sassoli and Daniele Nosi and Alessia Tani and Flaminia Chellini and Benedetta Mazzanti and Franco Quercioli and Sandra Zecchi and Lucia A. Formigli},
  journal={Experimental cell research},
  year={2014},
  volume={323 2},
  pages={
          297-313
        }
}
Recent studies indicate that mesenchymal stromal cell (MSC) transplantation improves healing of injured and diseased skeletal muscle, although the mechanisms of benefit are poorly understood. In the present study, we investigated whether MSCs and/or their trophic factors were able to regulate matrix metalloproteinase (MMP) expression and activity in different cells of the muscle tissue. MSCs in co-culture with C2C12 cells or their conditioned medium (MSC-CM) up-regulated MMP-2 and MMP-9… CONTINUE READING
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