Defining the role of matrix compliance and proteolysis in three-dimensional cell spreading and remodeling.

@article{Dikovsky2008DefiningTR,
  title={Defining the role of matrix compliance and proteolysis in three-dimensional cell spreading and remodeling.},
  author={Daniel Dikovsky and Havazelet Bianco-Peled and Dror Seliktar},
  journal={Biophysical journal},
  year={2008},
  volume={94 7},
  pages={2914-25}
}
Recent studies have identified extracellular matrix (ECM) compliance as an influential factor in determining the fate of anchorage-dependent cells. We explore a method of examining the influence of ECM compliance on cell morphology and remodeling in three-dimensional culture. For this purpose, a biological ECM analog material was developed to pseudo-independently alter its biochemical and physical properties. A set of 18 material variants were prepared with shear modulus ranging from 10 to 700… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Chitosan based biocomposite scaffolds for bone tissue engineering.

International journal of biological macromolecules • 2016
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Intrinsicmechanical properties of the extracellular matrix affect the behavior of pre-osteoblastic MC3T3–E1 cells

C. B. Khatiwala, S.R.Peyton, andA.J. Putnam
Am. J. Physiol. Cell Physiol. 290:C1640–C1650 • 2006

Similar Papers

Loading similar papers…