Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

@article{Semenza2010DefiningTR,
  title={Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics},
  author={Gregg L Semenza},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={625-634}
}
Adaptation of cancer cells to their microenvironment is an important driving force in the clonal selection that leads to invasive and metastatic disease. O2 concentrations are markedly reduced in many human cancers compared with normal tissue, and a major mechanism mediating adaptive responses to reduced O2 availability (hypoxia) is the regulation of transcription by hypoxia-inducible factor 1 (HIF-1). This review summarizes the current state of knowledge regarding the molecular mechanisms by… CONTINUE READING
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