Defining the role of aprotinin in heart transplantation.

  title={Defining the role of aprotinin in heart transplantation.},
  author={Thomas W Prendergast and Satoshi Furukawa and A J Beyer and Howard J. Eisen and James B. McClurken and Valluvan Jeevanandam},
  journal={The Annals of thoracic surgery},
  volume={62 3},
BACKGROUND Heart transplantation is associated with excessive bleeding due to recipient coagulopathy, frequent need for reoperative median sternotomy, and prolonged cardiopulmonary bypass. Aprotinin reduces bleeding and the inflammatory response after cardiopulmonary bypass, but there are concerns about efficacy and side effects. METHODS To determine the role of aprotinin in primary and reoperative sternotomy heart transplantation, we studied 70 patients undergoing heart transplantation… CONTINUE READING