Defining the role of T cell-derived leptin in the modulation of hepatic or intestinal inflammation in mice.

@article{Fantuzzi2005DefiningTR,
  title={Defining the role of T cell-derived leptin in the modulation of hepatic or intestinal inflammation in mice.},
  author={Giamila Fantuzzi and Joseph A Sennello and Arvind Batra and Inka Fedke and Hans Anton Lehr and Martin Zeitz and Britta Siegmund},
  journal={Clinical and experimental immunology},
  year={2005},
  volume={142 1},
  pages={31-8}
}
The role of leptin in the immune system has been well established. While adipocytes represent the major source, leptin production by lymphocytes, infiltrating at the site of inflammation, was recently demonstrated. However, the significance of this locally released leptin remains unresolved. In the present study, two models in which absence of leptin-signalling is associated with protection were employed: the model of ConA-induced hepatitis and the CD4(+)CD45Rb(high) transfer model of colitis… CONTINUE READING
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