Defining the rate-limiting processes of bacterial cytokinesis.

@article{Coltharp2016DefiningTR,
  title={Defining the rate-limiting processes of bacterial cytokinesis.},
  author={Carla Coltharp and Jackson A Buss and Trevor M Plumer and Jie Xiao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 8},
  pages={E1044-53}
}
Bacterial cytokinesis is accomplished by the essential 'divisome' machinery. The most widely conserved divisome component, FtsZ, is a tubulin homolog that polymerizes into the 'FtsZ-ring' ('Z-ring'). Previous in vitro studies suggest that Z-ring contraction serves as a major constrictive force generator to limit the progression of cytokinesis. Here, we applied quantitative superresolution imaging to examine whether and how Z-ring contraction limits the rate of septum closure during cytokinesis… CONTINUE READING