Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms.

@article{Andreasen1999DefiningTP,
  title={Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms.},
  author={Nancy C. Andreasen and Peg Nopoulos and Daniel S. O'Leary and Del D. Miller and Thomas H. Wassink and Michael A Flaum},
  journal={Biological psychiatry},
  year={1999},
  volume={46 7},
  pages={908-20}
}
All research on schizophrenia depends on selecting the correct phenotype to define the sample to be studied. Definition of the phenotype is complicated by the fact that there are no objective markers for the disorder. Further, the symptoms are diverse, leading some to propose that the disorder is heterogeneous and not a single disorder or syndrome. This article explores an alternative possibility. It proposes that schizophrenia may be a single disorder linked by a common pathophysiology (a… CONTINUE READING
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