Defining the involvement of proteinases in pemphigus vulgaris: evidence of matrix metalloproteinase-9 overexpression in experimental models of disease.

@article{Cirillo2007DefiningTI,
  title={Defining the involvement of proteinases in pemphigus vulgaris: evidence of matrix metalloproteinase-9 overexpression in experimental models of disease.},
  author={Nicola Cirillo and Michele Lanza and Luigi Rossiello and Fernando Gombos and Alessandro Lanza},
  journal={Journal of cellular physiology},
  year={2007},
  volume={212 1},
  pages={36-41}
}
Pemphigus vulgaris (PV) acantholysis represents a complex phenomenon wherein a number of factors cooperates. PV serum is known to modulate important cellular events, including kinase activity, transcriptional regulation, and proteinase expression. Indeed, transduction of signals to the cell triggered by PV serum may induce proteinase up-regulation potentially responsible for disruption of epidermal adhesion and, ultimately, blister formation. Here, we sought to investigate this hypothesis by… CONTINUE READING