Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells.

  title={Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells.},
  author={William E Lowry and C{\'e}dric Blanpain and Jonathan A. Nowak and G{\'e}raldine Guasch and Lisa A Lewis and Elaine Fuchs},
  journal={Genes & development},
  volume={19 13},
Wnt signaling has been implicated in stem cell (SC) biology, but little is known about how stabilized beta-catenin functions within native SC niches. We address this by defining the impact of beta-catenin stabilization on maintenance, proliferation, and lineage commitment of multipotent follicle SCs when in their native niche and in culture. We employ gain of function mutations and inducible loss of function mutations to demonstrate that beta-catenin stabilization is essential for promoting the… CONTINUE READING

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