Defining the human targets of phorbol ester and diacylglycerol.


Phorbol esters (PEs) and their derivatives are potent tumor-promoting agents. The best known receptors for these substances are the novel and classical isotypes of protein kinase C (PKC), which bind PE and the physiological second messenger diacylglycerol (DAG) by cysteine-rich domains, the C1 domains. However, PKC is not the sole receptor of PE, a concept… (More)


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@article{Geiger2003DefiningTH, title={Defining the human targets of phorbol ester and diacylglycerol.}, author={Markus Geiger and Oliver A Wrulich and Marcel Jenny and Wolfgang Schwaiger and Hans H. Grunicke and Florian Uberall}, journal={Current opinion in molecular therapeutics}, year={2003}, volume={5 6}, pages={631-41} }